As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

To ensure accurate duplication of genetic material, the replication fork must overcome
numerous natural obstacles on its way, including transcription complexes engaged along …

Frequent codirectional collisions between the replisome and RNA polymerase (RNAP) are
inevitable because the rate of replication is much faster than that of transcription. Here we …

Alterations in genome sequence and structure contribute to somatic disease, affect the
fitness of subsequent generations and drive evolutionary processes. The crucial roles of …

Many bacterial cellular processes interact intimately with the chromosome. Such interplay is
the major driving force of genome structure or organization. Interactions take place at …

DNA replication and transcription use the same template and occur concurrently in bacteria.
The lack of temporal and spatial separation of these two processes leads to their conflict …

How living cells deal with head‐on collisions of the replication and transcription complexes
has been debated for a long time. Even in the widely studied model bacteria Escherichia …

DNA and RNA polymerases clash along the genome as they compete for the same DNA
template. Cells have evolved specialized strategies to prevent and resolve replication and …

All viable bacterial cells, whether they divide symmetrically or asymmetrically, must
coordinate their growth, division, cell volume and shape with the inheritance of the genome …

In many bacteria, there is a genome-wide bias towards co-orientation of replication and
transcription, with essential and/or highly-expressed genes further enriched co-directionally …