Outcomes for patients with chronic myeloid leukemia (CML) have substantially improved
due to advances in drug development and rational treatment intervention strategies. Despite …

Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation
and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Acute lymphoblastic leukaemia (ALL) occurs in approximately 1: 1500 children and is less
frequently found in adults. The most common immunophenotype of ALL is the B cell lineage …

Children with Down syndrome (DS) are prone to development of high-risk B-cell precursor
ALL (DS-ALL), which differs genetically from most sporadic pediatric ALLs. Increased …

Advances in genomics have deepened our understanding of the biology of acute
lymphoblastic leukemia (ALL), defined novel molecular leukemia subtypes, discovered new …

Simple Summary Phosphoinositol signaling pathways and their dysregulation have been
shown to have a fundamental role in health and disease, respectively. The SH2-containing …

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk B-cell Acute
Lymphoblastic Leukemia (B-ALL) characterized by a gene expression profile similar to Ph …