In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli
because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

▪ Abstract Recent studies in transgenic mice have revealed important insights into the roles
of GM-CSF in regulation of surfactant homeostasis and lung host defense. Interruption of the …

A hallmark of the immune system is the interplay among specialized cell types transitioning
between resting and stimulated states. The gene regulatory landscape of this dynamic …

Tissue macrophages comprise a heterogeneous group of cell types differing in location,
surface markers and function. Red pulp macrophages are a distinct splenic subset involved …

Here we develop a high-throughput single-cell ATAC-seq (assay for transposition of
accessible chromatin) method to measure physical access to DNA in whole cells. Our …

Background Microglia play critical roles in the brain during homeostasis and pathological
conditions. Understanding the molecular events underpinning microglial functions and …

PU. 1 is an Ets family transcription factor that is essential for fetal liver hematopoiesis. We
have generated a PU. 1 gfp reporter strain that allowed us to examine the expression of PU …

During hematopoiesis, myeloid progenitor cells give rise to granulocytes and macrophages.
To study the role for ICSBP, a hematopoietic cell-specific transcription factor in myeloid cell …

Cellular responses to environmental stimuli are controlled by a series of signaling cascades
that transduce extracellular signals from ligand-activated cell surface receptors to the …

Although the transcription factor PU. 1 is essential for fetal lymphomyelopoiesis, we
unexpectedly found that elimination of the gene in adult mice allowed disturbed …