Role of insulin in health and disease: an update
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …
Treatment strategies against diabetes: Success so far and challenges ahead
R Khursheed, SK Singh, S Wadhwa, B Kapoor… - European journal of …, 2019 - Elsevier
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy
As a promising cancer treatment, photodynamic therapy (PDT) still achieved limited clinical
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …
[HTML][HTML] Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
A Malaekeh-Nikouei, S Shokri-Naei… - Biomedicine & …, 2023 - Elsevier
In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …
Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus
X Zhang, H Jiang, X Ma, H Wu - Journal of diabetes …, 2020 - Wiley Online Library
Abstract Aims/Introduction Asprosin is a novel secreted adipokine that is induced by fasting
and promotes hepatic glucose release. In healthy humans, circulating asprosin shows …
and promotes hepatic glucose release. In healthy humans, circulating asprosin shows …
The vital role of ATP citrate lyase in chronic diseases
Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …
usually result in long-term illnesses and demand long-term care. Despite advances in …
Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels?
M Wakeman, DT Archer - Diabetes, Metabolic Syndrome and …, 2020 - Taylor & Francis
Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …
Investigation of plasma asprosin and saliva levels in newly diagnosed type 2 diabetes mellitus patients treated with metformin
Introduction: Asprosin is a hormone that was first reported by Romere et al.[2016]. Its
secretion is induced in the case of starvation. Asprosin promotes hepatic glucose release …
secretion is induced in the case of starvation. Asprosin promotes hepatic glucose release …
The apelin/APJ system as a therapeutic target in metabolic diseases
I Castan-Laurell, B Masri, P Valet - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-
coupled receptor which is widely expressed in peripheral tissues and in the central nervous …
coupled receptor which is widely expressed in peripheral tissues and in the central nervous …
Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin‐Induced Diabetic Rats
Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional
properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia …
properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia …