Role of insulin in health and disease: an update

MS Rahman, KS Hossain, S Das, S Kundu… - International journal of …, 2021 - mdpi.com
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

Treatment strategies against diabetes: Success so far and challenges ahead

R Khursheed, SK Singh, S Wadhwa, B Kapoor… - European journal of …, 2019 - Elsevier
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …

Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy

Z Zhou, Y Liu, W Song, X Jiang, Z Deng… - Journal of Controlled …, 2022 - Elsevier
As a promising cancer treatment, photodynamic therapy (PDT) still achieved limited clinical
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …

[HTML][HTML] Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins

A Malaekeh-Nikouei, S Shokri-Naei… - Biomedicine & …, 2023 - Elsevier
In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus

X Zhang, H Jiang, X Ma, H Wu - Journal of diabetes …, 2020 - Wiley Online Library
Abstract Aims/Introduction Asprosin is a novel secreted adipokine that is induced by fasting
and promotes hepatic glucose release. In healthy humans, circulating asprosin shows …

The vital role of ATP citrate lyase in chronic diseases

AD Khwairakpam, K Banik, S Girisa… - Journal of Molecular …, 2020 - Springer
Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …

Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels?

M Wakeman, DT Archer - Diabetes, Metabolic Syndrome and …, 2020 - Taylor & Francis
Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …

Investigation of plasma asprosin and saliva levels in newly diagnosed type 2 diabetes mellitus patients treated with metformin

N Gozel, F Kilinc - Endokrynologia Polska, 2021 - journals.viamedica.pl
Introduction: Asprosin is a hormone that was first reported by Romere et al.[2016]. Its
secretion is induced in the case of starvation. Asprosin promotes hepatic glucose release …

The apelin/APJ system as a therapeutic target in metabolic diseases

I Castan-Laurell, B Masri, P Valet - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-
coupled receptor which is widely expressed in peripheral tissues and in the central nervous …

Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin‐Induced Diabetic Rats

E Farida, L Nuraida, PE Giriwono… - International Journal of …, 2020 - Wiley Online Library
Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional
properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia …