The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …
preclinical models and clinical studies of depression have revealed an array of structural …
Ketamine and serotonergic psychedelics: an update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment
The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …
understand its underlying mechanisms of action and to identify other novel compounds that …
Ketamine and serotonergic psychedelics: common mechanisms underlying the effects of rapid-acting antidepressants
Background The glutamatergic modulator ketamine has created a blueprint for studying
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …
Measuring acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans using TD-fNIRS
Quantifying neural activity in natural conditions (ie conditions comparable to the standard
clinical patient experience) during the administration of psychedelics may further our …
clinical patient experience) during the administration of psychedelics may further our …
Ketamine in neuropsychiatric disorders: an update
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
A unified model of ketamine's dissociative and psychedelic properties
M Marguilho, I Figueiredo… - Journal of …, 2023 - journals.sagepub.com
Ketamine is an N-methyl-d-aspartate antagonist which is increasingly being researched and
used as a treatment for depression. In low doses, it can cause a transitory modification in …
used as a treatment for depression. In low doses, it can cause a transitory modification in …
Imaging synaptic density in depression
Major depressive disorder is a prevalent and heterogeneous disorder with treatment
resistance in at least 50% of individuals. Most of the initial studies focused on the …
resistance in at least 50% of individuals. Most of the initial studies focused on the …
Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome
Z Yang, L Jian, H Qiu, C Zhang, S Cheng, J Ji… - Translational …, 2021 - nature.com
Brain function relies on efficient communications between distinct brain systems. The
pathology of major depressive disorder (MDD) damages functional brain networks, resulting …
pathology of major depressive disorder (MDD) damages functional brain networks, resulting …
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
R Shinohara, GK Aghajanian, CG Abdallah - Biological Psychiatry, 2021 - Elsevier
The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm
shift in our perception of what is possible in treating severe depression; 2) spurred a wave of …
shift in our perception of what is possible in treating severe depression; 2) spurred a wave of …
Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies
GC Medeiros, M Matheson, I Demo, MJ Reid… - The Lancet …, 2023 - thelancet.com
Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …
response and the precise mechanism of action is unclear. Neuroimaging can provide …