[HTML][HTML] The contribution of Neanderthal introgression to modern human traits
Neanderthals, our closest extinct relatives, lived in western Eurasia from 400,000 years ago
until they went extinct around 40,000 years ago. DNA retrieved from ancient specimens …
until they went extinct around 40,000 years ago. DNA retrieved from ancient specimens …
To be frail or not to be frail: this is the question—a critical narrative review of frailty
S Sciacchitano, V Carola, G Nicolais… - Journal of Clinical …, 2024 - mdpi.com
Many factors have contributed to rendering frailty an emerging, relevant, and very popular
concept. First, many pandemics that have affected humanity in history, including COVID-19 …
concept. First, many pandemics that have affected humanity in history, including COVID-19 …
Genotype× environment interactions in gene regulation and complex traits
C Boye, S Nirmalan, A Ranjbaran, F Luca - Nature Genetics, 2024 - nature.com
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …
underlying human phenotypic variation. Technological developments over the past 15 years …
rs71327024 Associated with COVID-19 Hospitalization Reduces CXCR6 Promoter Activity in Human CD4+ T Cells via Disruption of c-Myb Binding
Single-nucleotide polymorphism rs71327024 located in the human 3p21. 31 locus has been
associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21 …
associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21 …
Functional characterization of archaic-specific variants in mitonuclear genes: insights from comparative analysis in S. cerevisiae
S Aneli, C Ceccatelli Berti, AI Gilea… - Human Molecular …, 2024 - academic.oup.com
Neanderthal and Denisovan hybridisation with modern humans has generated a non-
random genomic distribution of introgressed regions, the result of drift and selection …
random genomic distribution of introgressed regions, the result of drift and selection …
Using Portuguese BRCA pathogenic variation as a model to study the impact of human admixture on human health
Admixture occurs between different ethnic human populations. The global colonization in
recent centuries by Europeans led to the most significant admixture in human history. While …
recent centuries by Europeans led to the most significant admixture in human history. While …
Long-range regulatory effects of Neandertal DNA in modern humans
D Yermakovich, V Pankratov, U Võsa, B Yunusbayev… - Genetics, 2023 - academic.oup.com
The admixture between modern humans and Neandertals has resulted in∼ 2% of the
genomes of present-day non-Africans being composed of Neandertal DNA. Introgressed …
genomes of present-day non-Africans being composed of Neandertal DNA. Introgressed …
Role of the Neanderthal Genome in Genetic Susceptibility to COVID-19: 3p21. 31 Locus in the Spotlight
M Yaghmouri, P Izadi - Biochemical Genetics, 2024 - Springer
Since the outbreak of COVID-19, genome-wide association studies have tried to discover
the role of genetic predisposition in the clinical variability of this viral infection. The findings …
the role of genetic predisposition in the clinical variability of this viral infection. The findings …
Worldwide distribution of genetic factors related to severity of COVID-19 infection
ME Esteban, D Pino, A Romero-Lorca… - Annals of Human …, 2024 - Taylor & Francis
Background Genome-wide association studies of COVID-19 severity have been carried out
mostly on European or East Asian populations with small representation of other world …
mostly on European or East Asian populations with small representation of other world …
[引用][C] Long-range regulatory effects of Neandertal DNA in modern humans
M Dannemann - GENETICS, 2023 - europepmc.org
The admixture between modern humans and Neandertals has resulted in∼ 2% of the
genomes of present-day non-Africans being composed of Neandertal DNA. Introgressed …
genomes of present-day non-Africans being composed of Neandertal DNA. Introgressed …