Over the past decade, various liquid biopsy techniques have emerged as viable alternatives
to the analysis of traditional tissue biopsy samples. Such surrogate 'biopsies' offer numerous …

Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …

Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …

Nearly one-third of children with medulloblastoma, a malignant embryonal tumor of the
cerebellum, succumb to their disease. Conventional response monitoring by imaging and …

Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because
quantities in body fluids are low. We determined the glioma‐derived DNA fraction in …

The molecular characterisation of medulloblastoma, the most common paediatric brain
tumour, is crucial for the correct management and treatment of this heterogenous disease …

Background There is an extensive literature highlighting the utility of blood-based liquid
biopsies in several extracranial tumors for diagnosis and monitoring. Methods The RANO …

Epigenetic mechanisms play instrumental roles in gene regulation during embryonic
development and disease progression. However, it is challenging to non-invasively monitor …

Challenges in obtaining tissue specimens from patients with brain tumours limit the
diagnosis and molecular characterisation and impair the development of better therapeutic …