The specificities of thrombotic thrombocytopenic purpura at extreme ages: a narrative review

A Joseph, BS Joly, A Picod, A Veyradier… - Journal of Clinical …, 2023 - mdpi.com
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic
microangiopathy (TMA) related to a severe ADAMTS13 deficiency, the specific von …

Should we consider caplacizumab as routine treatment for acute thrombotic thrombocytopenic purpura? An expert perspective on the pros and cons

IG Seguí, ME Mingot Castellano… - Expert Review of …, 2024 - Taylor & Francis
Introduction Immune thrombotic thrombocytopenic purpura (iTTP) is a rare and life-
threatening disorder. Caplacizumab has been the latest drug incorporated into the initial …

Novel mechanisms of action of emerging therapies of hereditary thrombotic thrombocytopenic purpura

XL Zheng - Expert Review of Hematology, 2024 - Taylor & Francis
Introduction Hereditary thrombotic thrombocytopenic purpura (hTTP) is caused by deficiency
of plasma ADAMTS13 activity, resulting from ADAMTS13 mutations. ADAMTS13 cleaves …

Clinical features and neurological outcomes in pediatric immune‐mediated thrombotic thrombocytopenic purpura: a report from a large pediatric hematology center

S Graciaa, S Adeagbo, G Fong, M Rollins… - Pediatric Blood & …, 2022 - Wiley Online Library
Background Thrombotic thrombocytopenic purpura (TTP) is a potentially life‐threatening
disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and …

Caplacizumab as an add-on therapy in a 7-year-old girl with exacerbated immune-mediated thrombotic thrombocytopenic purpura, a case report and literature review

L Chavaz, L Cimasoni, JA Kremer Hovinga… - Frontiers in …, 2024 - frontiersin.org
The cornerstone treatment for immune-mediated thrombotic thrombocytopenic purpura
(iTTP) in children is a combination of therapeutic plasma exchange (TPE), corticosteroids …

Successful Treatment of Acquired Thrombotic Thrombocytopenic Purpura With Caplacizumab Combined With Plasma Exchanges and Immune Suppression in 3 …

II Kalinina, KS Antonova, PV Avdonin… - Journal of Pediatric …, 2024 - journals.lww.com
Acquired thrombotic thrombocytopenic (aTTP) purpura is a life-threatening condition that
can lead to devastating thromboembolic events. Recently, caplacizumab has been shown to …