Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-
coupled receptors that have evolved relatively recently. Of these, MRGPRX2 and MRGPRX4 …

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are
marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens …

To identify itch-related mediators and receptors that are differentially expressed in pruritic
skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired …

Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical
and functional associations with sensory afferent neurons. We reveal that epidermal nerve …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …

The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic
secretagogues and neurokinins. A number of commonly used small-molecule drugs (eg …