γ-Secretase in Alzheimer's disease
JY Hur - Experimental & molecular medicine, 2022 - nature.com
Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
Proteolytic degradation of amyloid β-protein
T Saido, MA Leissring - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …
The proteasomal system
T Jung, B Catalgol, T Grune - Molecular aspects of medicine, 2009 - Elsevier
Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …
The γ-secretase complex: from structure to function
One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
Cyclophilin–CD147 interactions: a new target for anti-inflammatory therapeutics
V Yurchenko, S Constant… - Clinical & …, 2010 - academic.oup.com
CD147 is a widely expressed plasma membrane protein that has been implicated in a
variety of physiological and pathological activities. It is best known for its ability to function as …
variety of physiological and pathological activities. It is best known for its ability to function as …
Development and mechanism of γ-secretase modulators for Alzheimer's disease
CJ Crump, DS Johnson, YM Li - Biochemistry, 2013 - ACS Publications
γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin,
Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid …
Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid …
Intramembrane proteolysis by γ-secretase
H Steiner, R Fluhrer, C Haass - Journal of Biological Chemistry, 2008 - ASBMB
γ-Secretase mediates the final proteolytic cleavage, which liberates amyloid β-peptide (Aβ),
the major component of senile plaques in the brains of Alzheimer disease patients …
the major component of senile plaques in the brains of Alzheimer disease patients …
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration
Protein quality control ensures the degradation of damaged and misfolded proteins.
Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The …
Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The …
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species
J Bien, T Jefferson, M Čaušević, T Jumpertz… - Journal of Biological …, 2012 - ASBMB
The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering
from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to …
from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to …
BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells
J Cui, W Zhang, E Huang, J Wang, J Liao, R Li… - Laboratory …, 2019 - nature.com
Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into
multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a …
multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a …