Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

CD147 is a widely expressed plasma membrane protein that has been implicated in a
variety of physiological and pathological activities. It is best known for its ability to function as …

γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin,
Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid …

γ-Secretase mediates the final proteolytic cleavage, which liberates amyloid β-peptide (Aβ),
the major component of senile plaques in the brains of Alzheimer disease patients …

Protein quality control ensures the degradation of damaged and misfolded proteins.
Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The …

The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering
from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to …

Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into
multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a …