Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …

Many viruses have learned to evade or subvert the host antiviral immune responses by
encoding and expressing immunomodulatory proteins that protect the virus from attack by …

Activation of microglia and the subsequently elevated inflammatory cytokine release in the
brain during surgery predispose individuals to cognitive dysfunction, also known as …

Background Multiple sclerosis (MS), a chronic auto-immune, inflammatory, and
degenerative disease of the central nervous system, affects both males and females; …

Myxoma virus (MYXV) gained importance throughout the twentieth century because of the
use of the highly virulent Standard Laboratory Strain (SLS) by the Australian government in …

Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative
agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural …

The study of viral pathogens with genomes as large and complex as poxviruses represents
a constant experimental challenge. Advances in recombinant DNA technologies have …

The serpins comprise an ancient superfamily of proteins, found abundantly in eukaryotes
and even in some bacteria and archea, that have evolved to regulate proteases of both …

Oncolytic virotherapy is an innovative alternative to more conventional cancer therapies. The
ability of some viruses to specifically target and kill malignant cancerous cells while leaving …

A massive localized trauma to the spinal cord results in complex pathologic events driven by
necrosis and vascular damage which in turn leads to hemorrhage and edema. Severe …