CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily.
Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and …

The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …

Most tumors are unresponsive to immune checkpoint blockade, especially if deep
immunosuppression in the tumor develops prior to and prevents T cell immunosurveillance …

The expression “immunogenic cell death”(ICD) refers to a functionally unique form of cell
death that facilitates (instead of suppressing) a T cell-dependent immune response specific …

Agonistic anti-CD40 monoclonal antibody (mAb) therapy in combination with chemotherapy
(chemoimmunotherapy) shows promise for the treatment of pancreatic ductal …

In the last decades, extensive research has been carried out on the understanding and
treatment of pancreatic cancer. Despite the significant advances in medicine and …

Malignant pleural mesothelioma (MPM) is an intractable disease with an extremely poor
prognosis. Our clinical protocol for MPM of subablative radiotherapy (RT) followed by radical …

Objective Pleural effusion (PE) is a common feature of malignant pleural mesothelioma.
These effusions typically contain lymphocytes and malignant cells. We postulated that the …

Systemic inflammation is a determinant of outcomes to CD40 agonist-based therapy in
pancreatic cancer patients Page 1 Systemic inflammation is a determinant of outcomes to …