MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene
expression in almost all biological events. In the past decade, the involvement of miRNAs in …

Signaling through the kinase Akt regulates many biological functions. Akt is activated during
growth factor stimulation through a process that requires binding of Akt to …

MicroRNA-21 (miR-21) is highly up-regulated during hypertrophic and cancerous cell
growth. In contrast, we found that it declines in cardiac myocytes upon exposure to hypoxia …

Cyclic GMP–phosphodiesterase type 5 (PDE5) inhibition has been shown to counteract
maladaptive cardiac changes triggered by diabetes in some but not all studies. We …

Background Triple-negative breast cancer (TNBC) remains a poor prognostic factor for
breast cancer since no effective targeted therapy is readily available. Our previous studies …

Heart failure (HF) imposes significant economic and public health burdens upon modern
society. It is known that disturbances in neurohormonal status play an important role in the …

Aims To demonstrate that pregnancy-related complications are associated with alterations in
cardiovascular and cerebrovascular microRNA expression. Gene expression of 32 …

Differential microRNA (miRNA or miR) regulation is linked to the development and progress
of many diseases, including inflammatory bowel disease (IBD). It is well-established that …

G protein-coupled receptors (GPCRs) are a family of cell-surface proteins that play critical
roles in regulating a variety of pathophysiological processes and thus are targeted by almost …