COVID-19 transmission, current treatment, and future therapeutic strategies

VS Salian, JA Wright, PT Vedell, S Nair… - Molecular …, 2021 - ACS Publications
At the stroke of the New Year 2020, COVID-19, a zoonotic disease that would turn into a
global pandemic, was identified in the Chinese city of Wuhan. Although unique in its …

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

M Aliyu, FT Zohora, AU Anka, K Ali, S Maleknia… - International …, 2022 - Elsevier
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …

[HTML][HTML] Recent advances in management of COVID-19: A review

S Mouffak, Q Shubbar, E Saleh, R El-Awady - Biomedicine & …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused and is still causing
significant mortality and economic consequences all over the globe. As of today, there are …

[HTML][HTML] Therapeutics for COVID-19 and post COVID-19 complications: An update

D Basu, VP Chavda, AA Mehta - Current Research in Pharmacology and …, 2022 - Elsevier
Since its inception in late December 2020 in China, novel coronavirus has affected the
global socio-economic aspect. Currently, the world is seeking safe and effective treatment …

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

TAC Snow, N Saleem, G Ambler, E Nastouli… - Intensive Care …, 2021 - Springer
Abstract Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and
severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a …

A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval

NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …

[HTML][HTML] The find of COVID-19 vaccine: Challenges and opportunities

M ElBagoury, MM Tolba, HA Nasser, A Jabbar… - Journal of infection and …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus (SARS-CoV-2), a novel corona virus,
causing COVID-19 with Flu-like symptoms is the first alarming pandemic of the third …

Overview of COVID-19 disease: virology, epidemiology, prevention diagnosis, treatment, and vaccines

I Salahshoori, N Mobaraki-Asl, A Seyfaee… - Biologics, 2021 - mdpi.com
Coronaviruses belong to the “Coronaviridae family”, which causes various diseases, from
the common cold to SARS and MERS. The coronavirus is naturally prevalent in mammals …

[HTML][HTML] A critical analysis of SARS-CoV-2 (COVID-19) complexities, emerging variants, and therapeutic interventions and vaccination strategies

CX Li, S Noreen, LX Zhang, M Saeed, PF Wu… - Biomedicine & …, 2022 - Elsevier
Coronavirus is a family of viruses that can cause diseases such as the common cold, severe
acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). The …

Tocilizumab in COVID-19: a study of adverse drug events reported in the WHO database

J Charan, S Dutta, R Kaur, P Bhardwaj… - Expert opinion on …, 2021 - Taylor & Francis
Background Elevated inflammatory cytokines in Coronavirus disease 2019 (COVID‐19)
affect the lungs leading to pneumonitis with a poor prognosis. Tocilizumab, a type of …