Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …

Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

Diabetes is the leading cause of severe health complications and one of the top 10 causes
of death worldwide. To date, diabetes has no cure, and therefore, it is necessary to take …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …

Objective To summarize the application of non-targeted metabolomics in epidemiological
studies that assessed metabolite and metabolic pathway alterations associated with per-and …

Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …