Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

The E2F transcription factor family determines whether or not a cell will divide by controlling
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct …

The stability of c-Myc is regulated by multiple Ras effector pathways. Phosphorylation at Ser
62 stabilizes c-Myc, whereas subsequent phosphorylation at Thr 58 is required for its …

Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …

▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell
biological experiments, yet allowing accurate molecular predictions and spurring a search …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

During the G 1 phase of the cell cycle, an E2F–RB complex represses transcription, via the
recruitment of histone deacetylase activity. Phosphorylation of RB at the G 1/S boundary …

Bop1 is a novel nucleolar protein involved in rRNA processing and ribosome assembly. We
have previously shown that expression of Bop1Δ, an amino-terminally truncated Bop1 that …