Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

The role of epigenetic change in autism spectrum disorders

YJ Loke, AJ Hannan, JM Craig - Frontiers in neurology, 2015 - frontiersin.org
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disorders characterized by problems with social communication, social interaction, and …

Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings

B Misiak, M Krefft, T Bielawski, AA Moustafa… - Neuroscience & …, 2017 - Elsevier
There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …

Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

Epigenetic mechanisms mediating the long-term effects of maternal care on development

FA Champagne, JP Curley - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
The long-term consequences of early environmental experiences for development have
been explored extensively in animal models to better understand the mechanisms mediating …

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder

HM Abdolmaleky, K Cheng, SV Faraone… - Human molecular …, 2006 - academic.oup.com
The variability in phenotypic presentations and the lack of consistency of genetic
associations in mental illnesses remain a major challenge in molecular psychiatry. Recently …

On the outside, looking in: a review and evaluation of the comparability of blood and brain “‐omes”

DS Tylee, DM Kawaguchi… - American Journal of …, 2013 - Wiley Online Library
In this article, we review studies detailing the correspondence between peripheral blood and
brain tissue across various domains of high‐throughput‐omic analysis in order to provide a …

DNA methylation and schizophrenia: current literature and future perspective

T Magwai, KB Shangase, FO Oginga, B Chiliza… - Cells, 2021 - mdpi.com
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Epigenetics of schizophrenia

A Srivastava, O Dada, J Qian, N Al-Chalabi… - Psychiatry …, 2021 - Elsevier
Schizophrenia (SCZ) is a chronic psychotic disorder that contributes significantly to
disability, affecting behavior, thought, and cognition. It has long been known that there is a …

Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset

PA Melas, M Rogdaki, U Ösby, M Schalling… - The FASEB …, 2012 - Wiley Online Library
Even though schizophrenia has a strong hereditary component, departures from simple
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …