Modeling neoplastic disease with spheroids and organoids

M Zanoni, M Cortesi, A Zamagni, C Arienti… - Journal of hematology & …, 2020 - Springer
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Cell motility in cancer invasion and metastasis: insights from simple model organisms

CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Cancer‐cell‐Activated in situ synthesis of mitochondria‐targeting AIE photosensitizer for precise photodynamic therapy

Y Wang, S Xu, L Shi, C Teh, G Qi… - Angewandte Chemie …, 2021 - Wiley Online Library
Maximization of phototoxic damage on tumor with minimized side effect on normal tissue is
essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer …

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

I Keklikoglou, C Cianciaruso, E Güç, ML Squadrito… - Nature cell …, 2019 - nature.com
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However,
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …

Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos

WS Lee, HJ Cho, E Kim, YH Huh, HJ Kim, B Kim… - Nanoscale, 2019 - pubs.rsc.org
As nano-and micro-sized plastics accumulate in the environment and the food chain of
animals, including humans, it is imperative to assess the effects of nanoplastics in living …

Zebrafish models for translational neuroscience research: from tank to bedside

AM Stewart, O Braubach, J Spitsbergen, R Gerlai… - Trends in …, 2014 - cell.com
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …

Zebrafish patient avatars in cancer biology and precision cancer therapy

M Fazio, J Ablain, Y Chuan, DM Langenau… - Nature Reviews …, 2020 - nature.com
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

R Fior, V Póvoa, RV Mendes… - Proceedings of the …, 2017 - National Acad Sciences
Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …

Cancer-cell-activated photodynamic therapy assisted by Cu (II)-based metal–organic framework

Y Wang, W Wu, J Liu, PN Manghnani, F Hu, D Ma… - ACS …, 2019 - ACS Publications
Activation of photosensitizers (PSs) in targeted lesion and minimization of reactive oxygen
species (ROS) depletion by endogenous antioxidants constitute promising approaches to …

Zebrafish models of cancer—new insights on modeling human cancer in a non-mammalian vertebrate

M Hason, P Bartůněk - Genes, 2019 - mdpi.com
Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …