Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Cell motility in cancer invasion and metastasis: insights from simple model organisms
CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
Cancer‐cell‐Activated in situ synthesis of mitochondria‐targeting AIE photosensitizer for precise photodynamic therapy
Maximization of phototoxic damage on tumor with minimized side effect on normal tissue is
essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer …
essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer …
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However,
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …
Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos
As nano-and micro-sized plastics accumulate in the environment and the food chain of
animals, including humans, it is imperative to assess the effects of nanoplastics in living …
animals, including humans, it is imperative to assess the effects of nanoplastics in living …
Zebrafish models for translational neuroscience research: from tank to bedside
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts
Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …
therapies, patients go through rounds of trial-and-error approaches to find the best …
Cancer-cell-activated photodynamic therapy assisted by Cu (II)-based metal–organic framework
Activation of photosensitizers (PSs) in targeted lesion and minimization of reactive oxygen
species (ROS) depletion by endogenous antioxidants constitute promising approaches to …
species (ROS) depletion by endogenous antioxidants constitute promising approaches to …
Zebrafish models of cancer—new insights on modeling human cancer in a non-mammalian vertebrate
M Hason, P Bartůněk - Genes, 2019 - mdpi.com
Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …
development and disease, including more recently cancer. The evolutionary conservation of …