Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

DNA replication stress can cause chromosomal instability and tumor progression. One key
pathway that counteracts replication stress and promotes faithful DNA replication consists of …

Fanconi Anemia (FA) is an inherited genomic instability disorder, caused by mutations in
genes regulating replication-dependent removal of interstrand DNA crosslinks. The Fanconi …

DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …

Fanconi's anemia is a rare disorder that arises from defective repair of damaged DNA. Of the
13 Fanconi's anemia genes, 3 are breast-cancer–susceptibility genes. One is identical to …

Mutations in any of at least sixteen FANC genes (FANCA–Q) cause Fanconi anemia, a
disorder characterized by sensitivity to DNA interstrand crosslinking agents. The clinical …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and
RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non …

The replicative machinery encounters many impediments, some of which can be overcome
by lesion bypass or replication restart pathways, leaving repair for a later time. However …

FANCM remodels branched DNA structures and plays essential roles in the cellular
response to DNA replication stress. Here, we show that FANCM forms a conserved DNA …