Carotenoids are among the best-known pigments in nature, confer color to plants and
animals, and are mainly derived from photosynthetic bacteria, fungi, algae, plants. Mammals …

Male fertility depends on the regulatory balance between germ cell self-renewal and
differentiation, and the spatial and temporal patterns of this balance must be maintained …

Oxidative stress is one of the major causes leading to male infertility including
asthenozoospermia. Hydrogen sulfide (H 2 S) has been widely recognized to be a potent …

Defective mini-puberty results in insufficient testosterone secretion that impairs the
differentiation of gonocytes into dark-type (Ad) spermatogonia. The differentiation of …

Chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq)
is a central genome-wide method for in vivo analyses of DNA-protein interactions in various …

Identifying effective internal factors for regulating germline commitment during development
and for maintaining spermatogonial stem cells (SSCs) self‐renewal is important to …

Retinoic acid (RA) plays a pivotal role in many cellular processes; however, the signaling
mechanisms mediating the effect of RA are not fully understood. Here, we show that RA …

Activating mutations in the human KIT receptor is known to drive severe hematopoietic
disorders and tumor formation spanning various entities. The most common mutation is the …

Atherosclerosis is the most common underlying cause of cardiovascular morbidity and
mortality worldwide. c-Kit (CD117) is a member of the receptor tyrosine kinase family, which …

Initiation of spermatogonial differentiation in the mouse testis begins with the response to
retinoic acid (RA) characterized by activation of KIT and STRA8 expression. In the adult …