Characterizing the structures, interactions, and dynamics of molecules in their native liquid
state is a long-existing challenge in chemistry, molecular science, and biophysics with …

High-quality specimen preparation plays a crucial role in cryo-electron microscopy (cryo-
EM) structural analysis. In this study, we have developed a reliable and convenient …

Air-water interface (AWI) interactions during cryo-electron microscopy (cryo-EM) sample
preparation cause significant sample loss, hindering structural biology research. Organisms …

With the development of cryo-electron microscopy (cryo-EM), high-resolution structures of
macromolecules can be reconstructed by the single particle method efficiently. However …

Specimen preparation is a critical but challenging step in high-resolution cryogenic electron
microscopy (cryo-EM) structural analysis of macromolecules. In the past decade, graphene …

Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex
structures. However, cryo-EM sample preparation remains challenging and inconsistent due …

The cryo-electron microscopy (cryoEM) method has enabled high-resolution structure
determination of numerous biomolecules and complexes. Nevertheless, cryoEM sample …

Cryogenic electron microscopy (cryoEM) has emerged as a powerful technique for probing
the atomic structure of macromolecular complexes. Sample preparation for cryoEM requires …

Revealing the underlying correlations between microscopic structures and the fundamental
physicochemical properties is essential for designing better functional materials. Cryogenic …

Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …