Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Most metastasizing tumor cells reach distant sites by entering the circulatory system. Within
the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Since Friedenstein and co-workers first reported bone marrow-derived mesenchymal stem
cells (MSCs) during the early 1970s, several researchers have focused on their biology and …

CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different
cells constituting vessels, particularly endothelial cells. The last 30 years of research in this …

Directional cell migration is a critical process underlying morphogenesis and post‐natal
tissue regeneration. During embryonic myogenesis, migration of skeletal myogenic …