Abstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …

Childhood tumors containing cells that are morphologically and functionally similar to
normal progenitor cells provide fertile ground for investigating the links between …

Purpose Identifying pathobiological correlates of clinical behavior or therapeutic response
currently represents a key challenge for medulloblastoma research. Nuclear accumulation of …

Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

The Wnt signaling pathway is one of the central morphogenic signaling pathways regulating
early vertebrate development. In recent years, it has become clear that the Wnt pathway also …

Lithium inhibits glycogen synthase kinase-3 (GSK-3) at therapeutic concentrations; however,
it is unclear if this inhibition and its downstream effects on specific signaling pathways are …

Alzheimer's disease (AD) is a neurodegenerative disorder with progressive dementia
accompanied by two main structural changes in the brain: intracellular protein deposits …

The cadherin/β-catenin adhesion complex is a key mediator of the bidirectional changes in
synapse strength which are believed to underlie complex learning and memory. In the …

More than two million American adults, or approximately one percent of the population 18
years or older, suffer from bipolar disorder. Current treatments include the so-called “mood …

Medulloblastoma is the most common brain tumor of childhood. Multiple signaling pathways
have been associated with medulloblastoma formation and growth. These include the …