This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing …

The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Congenital sodium diarrhea (CSD) refers to an intractable diarrhea of intrauterine onset with
high fecal sodium loss. CSD is clinically and genetically heterogeneous. Syndromic CSD is …

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal
peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause …

The transmembranal Na+/H+ antiporters transport sodium (or several other monovalent
cations) in exchange for H+ across lipid bilayers in all kingdoms of life. They are critical in …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
chronic relapsing inflammatory disorders of the gastrointestinal tract. Chronic inflammation …

Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly
regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases …

Objective Congenital sodium diarrhoea (CSD) refers to a form of secretory diarrhoea with
intrauterine onset and high faecal losses of sodium without congenital malformations. The …