The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of
function mutations in the genes encoding dystrophin, or the associated proteins, triggers …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

The muscular dystrophies are inherited myogenic disorders characterised by progressive
muscle wasting and weakness of variable distribution and severity. They can be subdivided …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal
muscle membrane. This large multicomponent complex has both mechanical stabilizing and …

Skeletal muscle can repair and regenerate due to resident stem cells known as satellite
cells. The muscular dystrophies are progressive muscle wasting diseases underscored by …

Muscular dystrophies comprise a diverse group of genetic disorders that lead to muscle
wasting and, in many instances, premature death. Many mutations that cause muscular …

Vascular smooth muscle cells (SMCs) are present in several phenotypic states in blood
vessels. They show a high degree of plasticity, undergoing rapid and reversible phenotypic …

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …

Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders
characterized by progressive muscle wasting and often premature death. The primary defect …