Although its exact mode of action is not known, gabapentin appears to have a unique effect
on voltage‐dependent calcium ion channels at the postsynaptic dorsal horns and may …

Co-morbid depression is common in patients with epilepsy and is often undiagnosed. The
manifestation of depression in epilepsy is multifaceted with many interacting neurobiological …

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat
restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed …

Patients with epilepsy are at high risk for depression because of an incompletely understood
combination of factors that may be both psychosocial and neurological. Interictal depression …

Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders
with success, failure, and controversy. A systematic review of the literature was performed to …

Mood disorders can be relatively straightforward or they can assume complex forms that are
difficult to treat. In this chapter, we review the epidemiology, diagnosis, comorbidity …

Objective: To conduct the first randomized, controlled trial assessing the prophylactic
efficacy of gabapentin in bipolar disorder. Method: We conducted a 1-year, double-blind …

Of the 9 new anticonvulsants that have been marketed recently in the UK or US, a number
appear to have either adverse or beneficial effects on behaviour. There is now a …

Neurosteroids are synthesized in the brain and modulate brain excitability. There is
increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their …

Although detoxification cannot, in itself, be considered a treatment for addiction, it is one of
the most pivotal phases. In order to facilitate entry into recovery and/or rehabilitation …