In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …

Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

Resistance of human tumors to anticancer drugs is most often ascribed to gene mutations,
gene amplification, or epigenetic changes that influence the uptake, metabolism, or export of …

Despite advances in developing novel therapeutic strategies, a major factor underlying
cancer related death remains resistance to therapy. In addition to biochemical resistance …

Cerium oxide nanoparticles (nanoceria) have shown great potential as antioxidant and
radioprotective agents for applications in cancer therapy. Recently, various polymer-coated …

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

As alterations in tissue pH underlie many pathological processes, the capability to image
tissue pH in the clinic could offer new ways of detecting disease and response to treatment …

The microenvironment within tumors is significantly different from that in normal tissues. A
major difference is seen in the chaotic vasculature of tumors, which results in unbalanced …

Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …