Linezolid can be considered as the first member of the class of oxazolidinone antibiotics.
The compound is a synthetic antibiotic that inhibits bacterial protein synthesis through …

Tuberculosis (TB) still represents a major public health issue in spite of the significant impact
of the efforts made by the World Health Organization (WHO) and partners to improve its …

Bedaquiline, a recently approved drug for the treatment of multidrug-resistant tuberculosis
(MDR-TB), is recommended for a duration of 24 weeks. There are scarce data on patients …

Abstract Background We evaluated Nix-TB trial data (NCT02333799, N= 109) to provide
dosing recommendations to potentially minimize linezolid toxicity in patients with extensively …

The classification of anti-tuberculosis (TB) drugs is important as it helps the clinician to build
an appropriate anti-TB regimen for multidrug-resistant (MDR) and extensively drug-resistant …

Background Linezolid was recently re‐classified as a Group A drug by the World Health
Organization (WHO) for treatment of multi‐drug resistant tuberculosis (MDR‐TB) and …

Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-
TB). However, dose-and duration-related toxicity limit its use. Here, our aim was to search …

Oxazolidinones are efficacious in treating mycobacterial infections, including tuberculosis
(TB) caused by drug-resistant Mycobacterium tuberculosis. In this study, we compared the in …

Although tuberculosis (TB) is preventable and curable, the lengthy treatment (generally 6
months), poor patient adherence, high inter-individual variability in pharmacokinetics (PK) …

Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen,
Mycobacterium tuberculosis (M. tb) and is responsible for the maximum number of deaths …