Ocular delivery of proteins and peptides: Challenges and novel formulation approaches
The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …
diseases over the past few decades has been advanced by substantial breakthroughs in …
Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
[HTML][HTML] Ocular delivery of therapeutic proteins: a review
DH Shastri, AC Silva, H Almeida - Pharmaceutics, 2023 - mdpi.com
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment
(ScFv), crystallizable fragment (Fc), and fragment antigen binding (Fab), have accounted for …
(ScFv), crystallizable fragment (Fc), and fragment antigen binding (Fab), have accounted for …
Biologics: an update and challenge of their pharmacokinetics
S Shi - Current Drug Metabolism, 2014 - ingentaconnect.com
Biologics, including but not limited to monoclonal antibodies (mAbs), cytokines, growth
factors, enzymes, hormones, vaccines, antibody fragments (eg Fabs), and antibody drug …
factors, enzymes, hormones, vaccines, antibody fragments (eg Fabs), and antibody drug …
Material and design toolkit for drug delivery: state of the art, trends, and challenges
The nanomaterial and related toolkit have promising applications for improving human
health and well-being. Nanobased drug delivery systems use nanoscale materials as …
health and well-being. Nanobased drug delivery systems use nanoscale materials as …
Unveiling Cytokine Charge Disparity as a Potential Mechanism for Immune Regulation
JM Messina, M Luo, MS Hossan, HA Gadelrab… - Cytokine & Growth …, 2023 - Elsevier
Cytokines are small signaling proteins that regulate the immune responses to infection and
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …
[HTML][HTML] Advanced delivery strategies facilitating oral absorption of heparins
G Fang, B Tang - Asian Journal of Pharmaceutical Sciences, 2020 - Elsevier
Heparins show great anticoagulant effect with few side effects, and are administered by
subcutaneous or intravenous route in clinics. To improve patient compliance, oral …
subcutaneous or intravenous route in clinics. To improve patient compliance, oral …
Unlocking the power of sugar: carbohydrate ligands as key players in nanotherapeutic-assisted targeted cancer therapy
R Swami, S Vij, S Sharma - Nanomedicine, 2024 - Future Medicine
Cancer cells need as much as 40-times more sugar than their normal cell counterparts. This
sugar demand is attained by the excessive expression of inimitable transporters on the …
sugar demand is attained by the excessive expression of inimitable transporters on the …
[图书][B] Handbook of preformulation: chemical, biological, and botanical drugs
SK Niazi - 2006 - taylorfrancis.com
Preformulation studies are the physical, chemical, and biological studies needed to
characterize a drug substance for enabling the proper design of a drug product, whereas the …
characterize a drug substance for enabling the proper design of a drug product, whereas the …
p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation
Dendrimers which are discrete nanostructures/nanoparticles are emerging as promising
candidates for many nanomedicine applications. Ligand-conjugated dendrimer facilitate the …
candidates for many nanomedicine applications. Ligand-conjugated dendrimer facilitate the …