Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

A Mandal, D Pal, V Agrahari, HM Trinh… - Advanced drug delivery …, 2018 - Elsevier
The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …

Small molecules as cancer targeting ligands: Shifting the paradigm

N Kaur, P Popli, N Tiwary, R Swami - Journal of Controlled Release, 2023 - Elsevier
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …

[HTML][HTML] Ocular delivery of therapeutic proteins: a review

DH Shastri, AC Silva, H Almeida - Pharmaceutics, 2023 - mdpi.com
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment
(ScFv), crystallizable fragment (Fc), and fragment antigen binding (Fab), have accounted for …

Biologics: an update and challenge of their pharmacokinetics

S Shi - Current Drug Metabolism, 2014 - ingentaconnect.com
Biologics, including but not limited to monoclonal antibodies (mAbs), cytokines, growth
factors, enzymes, hormones, vaccines, antibody fragments (eg Fabs), and antibody drug …

Material and design toolkit for drug delivery: state of the art, trends, and challenges

ME Rad, C Soylukan, PK Kulabhusan… - … Applied Materials & …, 2023 - ACS Publications
The nanomaterial and related toolkit have promising applications for improving human
health and well-being. Nanobased drug delivery systems use nanoscale materials as …

Unveiling Cytokine Charge Disparity as a Potential Mechanism for Immune Regulation

JM Messina, M Luo, MS Hossan, HA Gadelrab… - Cytokine & Growth …, 2023 - Elsevier
Cytokines are small signaling proteins that regulate the immune responses to infection and
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …

[HTML][HTML] Advanced delivery strategies facilitating oral absorption of heparins

G Fang, B Tang - Asian Journal of Pharmaceutical Sciences, 2020 - Elsevier
Heparins show great anticoagulant effect with few side effects, and are administered by
subcutaneous or intravenous route in clinics. To improve patient compliance, oral …

Unlocking the power of sugar: carbohydrate ligands as key players in nanotherapeutic-assisted targeted cancer therapy

R Swami, S Vij, S Sharma - Nanomedicine, 2024 - Future Medicine
Cancer cells need as much as 40-times more sugar than their normal cell counterparts. This
sugar demand is attained by the excessive expression of inimitable transporters on the …

[图书][B] Handbook of preformulation: chemical, biological, and botanical drugs

SK Niazi - 2006 - taylorfrancis.com
Preformulation studies are the physical, chemical, and biological studies needed to
characterize a drug substance for enabling the proper design of a drug product, whereas the …

p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation

R Swami, I Singh, H Kulhari, MK Jeengar… - Journal of Nanoparticle …, 2015 - Springer
Dendrimers which are discrete nanostructures/nanoparticles are emerging as promising
candidates for many nanomedicine applications. Ligand-conjugated dendrimer facilitate the …