The beneficial effects of statins are assumed to result from their ability to reduce cholesterol
biosynthesis. However, because mevalonic acid is the precursor not only of cholesterol, but …

Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have
proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are …

The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …

This review deals with polyketides produced by the filamentous fungus Monascus which
include: 1) a group of yellow, orange and red pigments, 2) a group of …

Background: The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A
reductase inhibitors) has revealed a number of unexpected beneficial effects, including a …

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
inhibitors (statins) on coronary events have generally been attributed to their …

Pools of farnesyl diphosphate and other phosphorylated products of the mevalonate
pathway are essential to the post-translational processing and physiological function of …

Recent evidence suggests that apoptosis may be involved in the control of vascular smooth
muscle cell (VSMC) number in atherosclerotic lesions. 3-Hydroxy-3-methylglutaryl …

Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors–HMG-CoA reductase
inhibitors) have been approved for the treatment of lipid disorders. Recently, in vivo studies …

Although statins are lipid-lowering drugs that block cholesterol biosynthesis, they exert
immunomodulatory, anti-inflammatory, anti-angiogenic and anti-proliferative functions by …