Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for
generating C20: 4 phospholipids and has been implicated in key biological processes such …

Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Phospholipids are major constituents of biological membranes. The fatty acyl chain
composition of phospholipids determines the biophysical properties of membranes and …

The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …

PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …