Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
Integrated cancer tissue engineering models for precision medicine
Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …
highly organized and interconnected organ systems. Tumor cells reside in complex …
Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism
Adipose tissue is an organized endocrine organ with important metabolic and
immunological functions and immune cell-adipocyte crosstalk is known to drive various …
immunological functions and immune cell-adipocyte crosstalk is known to drive various …
[HTML][HTML] Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines
DA Close, PA Johnston - SLAS Discovery, 2022 - Elsevier
In solid tumors like head and neck cancer (HNC), chronic and acute hypoxia have serious
adverse clinical consequences including poorer overall patient prognosis, enhanced …
adverse clinical consequences including poorer overall patient prognosis, enhanced …
Multi-center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: operation brain trauma therapy and beyond
PM Kochanek, CE Dixon, S Mondello… - Frontiers in …, 2018 - frontiersin.org
Current approaches have failed to yield success in the translation of neuroprotective
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …
High content screening characterization of head and neck squamous cell carcinoma multicellular tumor spheroid cultures generated in 384-well ultra-low attachment …
SJ Kochanek, DA Close, PA Johnston - ASSAY and Drug …, 2019 - liebertpub.com
Multicellular tumor spheroid (MCTS) cultures represent more physiologically relevant in vitro
cell tumor models that recapitulate the microenvironments and cell–cell or cell–extracellular …
cell tumor models that recapitulate the microenvironments and cell–cell or cell–extracellular …
Spheroids in cancer research: Recent advances and opportunities
In recent years, three-dimensional (3D) spheroid technology has emerged as a crucial
instrument in the realm of cancer research, offering a near-physiological model for probing …
instrument in the realm of cancer research, offering a near-physiological model for probing …
In vitro cancer models: a closer look at limitations on translation
In vitro cancer models are envisioned as high-throughput screening platforms for potential
new therapeutic discovery and/or validation. They also serve as tools to achieve …
new therapeutic discovery and/or validation. They also serve as tools to achieve …
Head and neck cancer stem cell-enriched spheroid model for anticancer compound screening
L Goričan, B Gole, U Potočnik - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs), a rare cell population in tumors, are resistant to conventional
chemotherapy and thus responsible for tumor recurrence. To screen for active compounds …
chemotherapy and thus responsible for tumor recurrence. To screen for active compounds …
[HTML][HTML] Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges
Cancer stem cells (CSCs) represent a subpopulation of cancer cells that are believed to
initiate and drive cancer progression. In animal models, xenotransplanted CSCs have …
initiate and drive cancer progression. In animal models, xenotransplanted CSCs have …