Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

In eukaryotes, three-dimensional genome organization is critical for transcriptional
regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin …

The eukaryotic epigenome is shaped by the genome topology in three-dimensional space.
Dynamic reversible variations in this epigenome structure directly influence the …

Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed
with heterochromatin by rearrangement or transposition. When heterochromatin packaging …

Noncoding RNAs have emerged as major components of the eukaryotic transcriptome.
Genome-wide analyses revealed the existence of thousands of long noncoding RNAs …

The global impact of DNA methylation on alternative splicing is largely unknown. Using a
genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we …

Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore
conceivable that chromatin-borne information participates in alternative splicing. Here we …

Eukaryotic genomes are packaged in two basic forms, euchromatin and heterochromatin.
We have examined the composition and organization of Drosophila melanogaster …