Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Solid tumors often exhibit simultaneously inflammatory and hypoxic microenvironments. The
'signal transducer and activator of transcription-3'(STAT3)-mediated inflammatory response …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

Abstract Hypoxia-inducible factor (HIF)-1α and HIF-2α are the main regulators of cellular
responses to hypoxia. Post-translational modifications of HIF-1α and 2α are necessary to …

Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …

Abstract Hypoxia-inducible factor-2α (Hif-2α) is a potential therapeutic target for
osteoarthritis (OA), but the application of this target in the delivery of therapeutic agents to …

Hypoxia is a prevalent attribute of the solid tumor microenvironment that promotes the
expression of genes through posttranslational modifications and stabilization of alpha …

The intestine is supported by a complex vascular system that undergoes dynamic and
transient daily shifts in blood perfusion, depending on the metabolic state. Moreover, the …

During prolonged hypoxic conditions, endothelial cells change their gene expression to
adjust to the low oxygen environment. This process is mainly regulated by the hypoxia …