Sepsis is a systemic inflammatory response syndrome caused by infection. The core
mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells …

Autophagy is an evolutionarily conserved process that promotes the lysosomal degradation
of intracellular components including organelles and portions of the cytoplasm. Besides …

Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They
are essential for the elongation and closure of the phagophore into a proper …

The NLRP3 inflammasome is a caspase‐1‐containing multi‐protein complex that controls
the release of IL‐1β and plays important roles in the development of inflammatory disease …

Autophagy is one of the innate immune defense mechanisms against microbial challenges.
Previous in vitro and in vivo models of sepsis demonstrated that autophagy was activated …

Background: Pyroptosis is the term for caspase-1-dependent cell death associated with pro-
inflammatory cytokines. The role of alveolar macrophage (AM) pyroptosis in the …

Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide
synthase (iNOS) is overexpressed in melanoma and other cancers, and previous data …

Recent studies have indicated that autophagy contributes to tumorigenesis and participates
in acquired chemotherapeutic resistance. The present study aimed to determine the function …

Background Autophagy is a major pathway of protein and organelle degradation in the
lysosome. Autophagy exists at basal constitutive level and can be induced as a defense …

Autophagy is a homeostatic and inducible process affecting multiple aspects of the immune
system. This intrinsic cellular process is involved in MHC-antigen (Ag) presentation …