RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene
regulation and genome evolution in diverse ways. More than half of the human genome …

Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …

The IntaRNA algorithm enables fast and accurate prediction of RNA–RNA hybrids by
incorporating seed constraints and interaction site accessibility. Here, we introduce …

The functional annotation of transcriptomes and identification of noncoding RNA (ncRNA)
classes has been greatly facilitated by the advent of next-generation RNA sequencing …

Summary mRNAs can fold into complex structures that regulate gene expression. Resolving
such structures de novo has remained challenging and has limited our understanding of the …

RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the
fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal …

Protein–RNA interactions regulate RNA fate and function, and defects can lead to various
disorders. Such interactions have mainly been studied by nucleoside-based UV crosslinking …

Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …