Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common
approach for the management of several disease states. Most notably, cholinesterase …

The incidence of neurodegenerative diseases, such as Alzheimer's disease (AD), increases
continuously demanding the urgent development of anti-Alzheimer's agents. Marine …

New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …

The marine sponges of the order Verongiida (Demospongiae: Porifera) have survived on
our planet for more than 500 million years due to the presence of a unique strategy of …

Alzheimer's disease is a neurodegenerative disorder that results in progressive and
irreversible central nervous system impairment, which has become one of the severe issues …

Herein, we describe the isolation and spectroscopic identification of eight new
tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis …

Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity
information to inform the strategy used for the isolation of new bioactive compounds …

Twenty bromotyrosine alkaloids, including a new compound, 13-oxosubereamolline D (5),
were isolated from the Thai sponge Acanthodendrilla sp. Their structures were determined …

Since the development of the “cholinergic hypothesis” as an important therapeutic approach
in the treatment of Alzheimer's disease (AD), the scientific community has made a …

Abstract Acanthodendrilline (1), a new bromotyrosine alkaloid, was isolated from the Thai
marine sponge Acanthodendrilla sp. The structure of 1 was fully characterized by …