The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

P Mehrbod, SR Ande, J Alizadeh, S Rahimizadeh… - Virulence, 2019 - Taylor & Francis
Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …

[HTML][HTML] Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Q Wan, D Song, H Li, M He - Signal transduction and targeted therapy, 2020 - nature.com
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Pathobiology of Japanese encephalitis virus infection

KB Sharma, S Vrati, M Kalia - Molecular Aspects of Medicine, 2021 - Elsevier
Japanese encephalitis virus (JEV) is a flavivirus, spread by the bite of carrier Culex
mosquitoes. The subsequent disease caused is Japanese encephalitis (JE), which is the …

[HTML][HTML] eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus

Y Li, W Jiang, Q Niu, Y Sun, C Meng, L Tan… - Cell death & …, 2019 - nature.com
Newcastle disease virus (NDV) causes severe infectious disease in poultry and selectively
kills tumor cells, by inducing apoptosis and cytokines secretion. In this report, we study the …

Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

U Ashraf, Z Ding, S Deng, J Ye, S Cao, Z Chen - Virulence, 2021 - Taylor & Francis
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by
Japanese encephalitis virus. During the virus infection of the central nervous system …

[HTML][HTML] The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress

M Luhr, ML Torgersen, P Szalai, A Hashim… - Journal of Biological …, 2019 - ASBMB
Endoplasmic reticulum (ER) stress is thought to activate autophagy via unfolded protein
response (UPR)-mediated transcriptional up-regulation of autophagy machinery …

The endoplasmic reticulum unfolded protein response–homeostasis, cell death and evolution in virus infections

V Prasad, UF Greber - FEMS microbiology reviews, 2021 - academic.oup.com
Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate
and adaptive immune responses, which limit infection. Viruses restore homeostasis by …

[HTML][HTML] Endoplasmic reticulum stress-associated neuronal death and innate immune response in neurological diseases

M Shi, Y Chai, J Zhang, X Chen - Frontiers in immunology, 2022 - frontiersin.org
Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

[HTML][HTML] Mechanisms of neuroinvasion and neuropathogenesis by pathologic flaviviruses

L de Vries, AT Harding - Viruses, 2023 - mdpi.com
Flaviviruses are present on every continent and cause significant morbidity and mortality. In
many instances, severe cases of infection with flaviviruses involve the invasion of and …

Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways

P Sun, J Jin, L Wang, J Wang, H Zhou, Q Zhang… - Veterinary …, 2021 - Elsevier
Porcine epidemic diarrhea virus (PEDV), the causative agent of PED, belongs to the genus
Alphacoronavirus in the family Coronaviridae. Reactive oxygen species (ROS), endoplasmic …