The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Ageing is characterized by the progressive impairment of physiological functions and
increased risk of developing debilitating disorders, including chronic inflammation and …

Cellular activity in the brain depends on the high energetic support provided by
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …

Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential
functional effects have been largely uninvestigated. The administration of the main active …

A major challenge in neuroscience is to determine the nanoscale position and quantity of
signaling molecules in a cell type–and subcellular compartment–specific manner. We …

Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …

Background: Anxiety and depressive disorders are highly prevalent. Patients are
increasingly using medicinal cannabis products to treat these disorders, but little is known …

Introduction: The high prevalence of adolescent cannabis use, the association between this
use and later psychiatric disease, and increased access to high-potency cannabis highlight …

Marijuana is the most widely used illicit drug among adolescents and young adults. Unique
cognitive, emotional, and social changes occur during this critical period of development …

Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid
(eCB) augmentation approaches in a variety of preclinical models. Pharmacological …