Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Making muscle: skeletal myogenesis in vivo and in vitro
J Chal, O Pourquié - Development, 2017 - journals.biologists.com
Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …
Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
A platform for generation of chamber-specific cardiac tissues and disease modeling
Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
Therapeutic approaches for cardiac regeneration and repair
H Hashimoto, EN Olson, R Bassel-Duby - Nature Reviews Cardiology, 2018 - nature.com
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
[HTML][HTML] Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
During embryogenesis, paracrine signaling between tissues in close proximity contributes to
the determination of their respective cell fate (s) and development into functional organs …
the determination of their respective cell fate (s) and development into functional organs …
Engineering adolescence: maturation of human pluripotent stem cell–derived cardiomyocytes
X Yang, L Pabon, CE Murry - Circulation research, 2014 - Am Heart Assoc
The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Directed differentiation protocols enable derivation of cardiomyocytes from human
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction
Since both myocardium and vasculature in the heart are excessively damaged following
myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently …
myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently …
Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …
decade ago, interest in their potential applications has increased exponentially. This has …