The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
[HTML][HTML] Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …
most common cause of human dementia. AD is characterized by accumulation of abnormal …
SIRT1 is downregulated by autophagy in senescence and ageing
Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …
range of biological events, including metabolism, the immune response and ageing …
Autophagy mediates degradation of nuclear lamina
Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …
process that degrades a variety of cellular constituents and is associated with human …
Mammalian autophagy: how does it work?
CF Bento, M Renna, G Ghislat, C Puri… - Annual review of …, 2016 - annualreviews.org
Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …
[HTML][HTML] Metabolic control of autophagy
Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved
mechanism of adaptation to adverse microenvironmental conditions, including limited …
mechanism of adaptation to adverse microenvironmental conditions, including limited …
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
CP Webster, EF Smith, CS Bauer, A Moller… - The EMBO …, 2016 - embopress.org
A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS/FTD) …
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS/FTD) …
[HTML][HTML] PI3K signalling in inflammation
PT Hawkins, LR Stephens - … et Biophysica Acta (BBA)-Molecular and Cell …, 2015 - Elsevier
PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
Classes of phosphoinositide 3-kinases at a glance
S Jean, AA Kiger - Journal of cell science, 2014 - journals.biologists.com
ABSTRACT The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways
T Jin, Y Zhang, BOA Botchway, J Zhang, R Fan… - Food and Chemical …, 2022 - Elsevier
Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …