The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Cycling cells duplicate their DNA content during S phase, following a defined program
called replication timing (RT). Early-and late-replicating regions differ in terms of mutation …

Early development is governed by the ability of pluripotent cells to retain the full range of
developmental potential and respond accurately to developmental cues. This property is …

Immediately following the discovery of the structure of DNA and the semi-conservative
replication of the parental DNA sequence into two new DNA strands, it became apparent …

During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

Three-dimensional genome organisation and replication timing are known to be correlated,
however, it remains unknown whether nuclear architecture overall plays an instructive role …

Recent findings provide evidence for a functional interplay between DNA replication and the
seemingly distinct areas of cancer, development and pluripotency. Protein complexes …

Background The POGZ gene has been found frequently mutated in neurodevelopmental
disorders (NDDs), particularly autism spectrum disorder (ASD) and intellectual disability (ID) …

Chromosome architecture has received a lot of attention since the recent development of
genome-scale methods to measure chromatin interactions (Hi-C), enabling the first …