An insight into prodrug strategy for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide. With 35 million
people over 60 suffering from dementia, new treatments for AD are immediately needed. In …
people over 60 suffering from dementia, new treatments for AD are immediately needed. In …
Glucagon/GLP-1 receptor co-agonists
J Day, J Patterson, J Chabenne, M Dimarchi… - US Patent …, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
39690775&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
39690775&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
RD DiMarchi, DL Smiley, M Dimarchi… - US Patent …, 2013 - Google Patents
Modified glucagon peptides are disclosed having improved solubility and/or half-life while
retaining glucagon agonist activity. The glycogen peptides have been modified by Sub …
retaining glucagon agonist activity. The glycogen peptides have been modified by Sub …
Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
RD DiMarchi, M Dimarchi, J Chabenne - US Patent 8,669,228, 2014 - Google Patents
4,275,152 A 6/1981 Esders et al. 5,359,030 A 10/1994 Ekwuribe(57) ABSTRACT 5,510,459
A 4/1996 Smith et al. 5,512,549 A 4/1996 Chen et a1. Modi? ed glucagon peptides are …
A 4/1996 Smith et al. 5,512,549 A 4/1996 Chen et a1. Modi? ed glucagon peptides are …
GIP-based mixed agonists for treatment of metabolic disorders and obesity
RD DiMarchi, T Ma - US Patent 9,062,124, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
41570802&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
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Amide based glucagon and superfamily peptide prodrugs
RD DiMarchi, B Kou - US Patent 8,969,288, 2015 - Google Patents
2009-12-18 Assigned to INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
RD DiMarchi, B Yang, B Finan - US Patent 9,127,088, 2015 - Google Patents
2012-01-09 Assigned to INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
Glucagon analogs exhibiting physiological solubility and stability
RD DiMarchi, DL Smiley - US Patent 8,338,368, 2012 - Google Patents
4,275,152 A 6, 1981 Esders et al. 5,359,030 A* 10/1994 Ekwuribe..................... 530/303
5,510,459 A* 4, 1996 Smith et al.................... 530/308 5,512,549 A 4, 1996 Chen et …
5,510,459 A* 4, 1996 Smith et al.................... 530/308 5,512,549 A 4, 1996 Chen et …
Glucagon/GLP-1 receptor co-agonists
RD DiMarchi, DL Smiley, M Dimarchi… - US Patent …, 2013 - Google Patents
2009-07-14 Assigned to INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
CORPORATION reassignment INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY …
Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
RD DiMarchi, B Yang, C Ouyang - US Patent 8,980,830, 2015 - Google Patents
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist
activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified …
activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified …