Advances in the treatment of sickle cell disease

S Kapoor, JA Little, LH Pecker - Mayo Clinic Proceedings, 2018 - Elsevier
Sickle cell disease (SCD) is a monogenic disorder that afflicts approximately 100,000
Americans and millions of people worldwide. It is characterized by hemolytic anemia, vaso …

Pain management issues as part of the comprehensive care of patients with sickle cell disease

BVKS Lakkakula, R Sahoo, H Verma… - Pain Management …, 2018 - Elsevier
Background Vaso-occlusive pain crisis is one of the primary complications of sickle cell
disease (SCD) and is responsible for the majority of hospital visits in patients with SCD …

[HTML][HTML] Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease

IA Khasabova, J Gable, M Johns, SG Khasabov… - …, 2023 - ncbi.nlm.nih.gov
Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of
SCD and opioids are the main treatment but their side effects emphasize the need for new …

A qualitative study of chronic pain and self-management in adults with sickle cell disease

N Matthie, D Ross, C Sinha, K Khemani… - Journal of the National …, 2019 - Elsevier
Acute, intermittent vaso-occlusive pain is the hallmark of sickle cell disease (SCD) and is
associated with substantial morbidity and impaired quality of life (QOL). The subgroup of …

Mechanisms of pain in sickle cell disease

K Takaoka, AC Cyril, S Jinesh… - British Journal of …, 2021 - journals.sagepub.com
Objectives: The hallmark of sickle cell disease (SCD) is acute and chronic pain, and the pain
dominates the clinical characteristics of SCD patients. Although pharmacological treatments …

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults

TE Cooper, IR Hambleton, SK Ballas… - Cochrane Database …, 2019 - cochranelibrary.com
Background Sickle cell disease (SCD) is a group of inherited disorders of haemoglobin (Hb)
structure in a person who has inherited two mutant globin genes (one from each parent), at …

Prevalence and predictors of chronic pain intensity and disability among adults with sickle cell disease

N Matthie, C Jenerette, A Gibson… - Health …, 2020 - journals.sagepub.com
Among 170 adults with sickle cell disease, we evaluated chronic pain impact and disability
prevalence, assessed age and gender differences, and identified psychosocial predictors of …

The effect of hypnosis on pain and peripheral blood flow in sickle-cell disease: a pilot study

RR Bhatt, SR Martin, S Evans, K Lung… - Journal of pain …, 2017 - Taylor & Francis
Background Vaso-occlusive pain crises (VOCs) are the “hallmark” of sickle-cell disease
(SCD) and can lead to sympathetic nervous system dysfunction. Increased sympathetic …

[HTML][HTML] Yoga Module Development and Validation for Sickle Cell Disease

SZH Zaidi, MV Mithila, RN Mavathur… - … Journal of Yoga, 2023 - journals.lww.com
Objective: To develop and validate a YM for SCD. Methodology: Concise literature reports
on yoga practices used for varied symptoms/comorbidities associated with SCD were …

Updated mechanisms underlying sickle cell disease-associated pain

S Du, C Lin, YX Tao - Neuroscience letters, 2019 - Elsevier
Sickle cell disease (SCD) is one of the most common severe genetic diseases around the
world. A majority of SCD patients experience intense pain, leading to hospitalization, and …