The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …

To study the late β-cell-specific function of the homeodomain protein IPF1/PDX1 we have
generated mice in which the Ipf1/Pdx1 gene has been disrupted specifically in β cells. These …

Oxidative stress is produced under diabetic conditions and possibly causes various forms of
tissue damage in patients with diabetes. The aim of this study was to examine the …

Insulin gene expression is restricted to islet β cells of the mammalian pancreas through
specific control mechanisms mediated in part by specific transcription factors 1, 2. The …

MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles
in differentiated β‐cells remain unclear. Here, we show that miRNA inactivation in β‐cells of …

Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic β-cell dysfunction found in diabetes. Possibly caused by low levels of …

Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often
leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a …

Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas
heterozygosity for PDX-1 mutations has been recently noted in some individuals with …

It is known well that activation of the hexosamine pathway causes insulin resistance, but
how this activation influences pancreatic β-cell function remains unclear. In this study, we …