Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species
(ROS) are widely believed to promote aging and age-related diseases, and antioxidants can …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Mobility of transposable elements (TEs) frequently leads to insertional mutations in
functional DNA regions. In the potentially immortal germline, TEs are effectively suppressed …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …