Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …

RNA origami is a method for designing RNA nanostructures that can self-assemble through
co-transcriptional folding with applications in nanomedicine and synthetic biology. However …

This paper describes the current update on macromolecular model validation services that
are provided at the MolProbity website, emphasizing changes and additions since the …

Predicting RNA three-dimensional structures from sequence could accelerate
understanding of the growing number of RNA molecules being discovered across biology …

MolProbity is a structure-validation web service that provides broad-spectrum solidly based
evaluation of model quality at both the global and local levels for both proteins and nucleic …

X-ray crystallography is a critical tool in the study of biological systems. It is able to provide
information that has been a prerequisite to understanding the fundamentals of life. It is also a …

Macromolecular X-ray crystallography is routinely applied to understand biological
processes at a molecular level. However, significant time and effort are still required to solve …

Here, we present an update of the CHARMM27 all‐atom additive force field for nucleic acids
that improves the treatment of RNA molecules. The original CHARMM27 force field …