Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology

AM Hersh, S Alomari, BM Tyler - International journal of molecular …, 2022 - mdpi.com
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

A historical review of brain drug delivery

WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Carbon dots: an innovative tool for drug delivery in brain tumors

G Calabrese, G De Luca, G Nocito, MG Rizzo… - International Journal of …, 2021 - mdpi.com
Simple Summary The pharmacological treatment of tumors of the central nervous system
poses major challenges due to the presence of physical obstacles, ie, the blood-brain …

Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Penetration and translocation of functional inorganic nanomaterials into biological barriers

Y Cong, D Baimanov, Y Zhou, C Chen… - Advanced Drug Delivery …, 2022 - Elsevier
With excellent physicochemical properties, inorganic nanomaterials (INMs) have exhibited a
series of attractive applications in biomedical fields. Biological barriers prevent successful …

Review on carbon dots: Synthesis and application in biology field

X Li, L Yu, M He, C Chen, Z Yu, S Jiang, Y Wang… - …, 2023 - Wiley Online Library
As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size,
stable chemical properties, excellent photoluminescence characteristics, but also exhibit …

Application of quantum dots in brain diseases and their neurotoxic mechanism

Y Hu, X Wang, Y Niu, K He, M Tang - Nanoscale Advances, 2024 - pubs.rsc.org
The early-stage diagnosis and therapy of brain diseases pose a persistent challenge in the
field of biomedicine. Quantum dots (QDs), nano-luminescent materials known for their small …

Emerging biomedical applications of carbon dot and polymer composite materials

GO Adam, SM Sharker, JH Ryu - Applied Sciences, 2022 - mdpi.com
Carbon dot-based composite materials have been extensively developed for versatile
biomedical applications, such as drug delivery, tissue engineering, bioimaging, biosensors …

Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots

JB Domena, BCLB Ferreira, EK Cilingir, Y Zhou… - Journal of colloid and …, 2023 - Elsevier
Over time, the interest in developing stable photosensitizers (PS) which both absorb and
emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently …

Structure–property–activity relationships in carbon dots

Y Zhou, W Zhang, RM Leblanc - The Journal of Physical Chemistry …, 2022 - ACS Publications
Carbon dots (CDs) are one of the most versatile nanomaterials discovered in the 21st
century. They possess many properties and thus hold potentials in diverse applications …