New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

The advent of immunotherapy, especially checkpoint inhibitor-based immunotherapy, has
provided novel and powerful weapons against cancer. Because only a subset of cancer …

Catecholamines released by sympathetic nerves can activate adrenergic receptors present
on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in …

Succinate acts as an extracellular mediator signaling through the G protein–coupled
receptor GPR91. Here we show that dendritic cells had high expression of GPR91. In these …

Exosomes are nanosized extracellular vesicles secreted by various cell types, including
those of the immune system, such as natural killer (NK) cells. They play a role in intercellular …

Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising
anticancer activities on diverse tumours. This review provides systematically organized …

The purpose of this study was to investigate the effects of six lichen metabolites (diffractaic
acid, lobaric acid, usnic acid, vicanicin, variolaric acid, protolichesterinic acid) on …

The delivery and accumulation of therapeutic drugs into cancer cells without affecting
healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a …

It has been for thousands of years in China known medicinal homologous foods that can be
employed both as foods and medicines to benefit human and animal health. These edible …

Myeloid-derived suppressor cells (MDSCs) inhibit adaptive and innate immunity and
accumulate in the blood of persons with cancer, chronic inflammation, trauma, infection, and …