The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Background Data about the effects of resistance exercise on level of IGF-1 in the serum are
conflicting. To resolve this inconsistency, we performed a systematic review and meta …

Context The associations of circulating insulin-like growth factor-1 (IGF-1) levels with bone
mineral density and fracture risk are inconclusive in observational studies. Objective We …

Background Aging is associated with progressive declines in immune responses leading to
increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a …

Abstract Metformin (Met), a first-line management for type 2 diabetes mellitus, has been
expansively employed and studied with results indicating its therapeutic potential extending …

Fragile X syndrome (FXS) is a rare genetic disorder characterized by a deficit of the fragile X
mental retardation protein (FMRP), encoded by the fragile X mental retardation gene (FMR1) …

Background and aim Inconsistencies exist with regard to the influence of
dehydroepiandrosterone (DHEA) supplementation on insulin-like growth factor 1 (IGF-1) …

Caloric restriction (CR), the reduction of caloric intake without inducing malnutrition, is the
most reproducible method of extending health and lifespan across numerous organisms …

Metformin has attracted increasing interest for its potential benefits in extending healthspan
and longevity. This study examined the effects of early-life metformin treatment on the …

A significantly higher probability of space radiation-induced gastrointestinal (GI) cancer
incidence and mortality after a Mars mission has been projected using biophysical and …